VANGL2 antibody (AA 1-489)

Catalog No. ABIN7869408

The Rabbit Polyclonal anti-VANGL2 antibody is suitable to detect VANGL2 in samples from Zebrafish (Danio rerio). It has been validated for WB and IHC (p).

Quick Overview for VANGL2 antibody (AA 1-489) (ABIN7869408)

Target: VANGL2 (Vang-Like 2 (VANGL2))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VANGL2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-VANGL2 Antibody

Binding Specificity: AA 1-489

Purpose: Zebrafish Vangl2 Antibody / Vang-like protein 2

Purification: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Vangl2 recombinant protein (amino acids M1-D489) was used as the immunogen for the Zebrafish Vangl2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Vangl2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Vangl2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for VANGL2

Target: VANGL2 (Vang-Like 2 (VANGL2))

Alternative Name: Vangl2

Background: Van Gogh-like protein 2 (Vangl2) is a core component of the planar cell polarity (PCP) pathway, a non-canonical Wnt signaling pathway that regulates the orientation and coordinated movement of cells within the plane of a tissue. In zebrafish (Danio rerio), Vangl2 plays a vital role in embryonic morphogenesis, particularly in convergent extension movements during gastrulation, which are essential for body axis elongation.

Zebrafish vangl2 is expressed early in development and is critical for establishing tissue polarity and directional cell migration. Mutations in vangl2-such as the well-studied trilobite mutant-lead to severe defects in neural tube formation, somite patterning, and organ positioning, making it a key model for understanding PCP signaling in vertebrates.

Given its high conservation and pivotal role in developmental processes, zebrafish Vangl2 is widely used to study cell polarity, tissue architecture, and congenital disorders such as neural tube defects. It also provides valuable insights into cytoskeletal organization, cell-cell communication, and signal integration during vertebrate development.

UniProt: Q8UVJ6

Pathways: WNT Signaling, Stem Cell Maintenance, Tube Formation, Asymmetric Protein Localization