APEX2 antibody (AA 1-500)

Catalog No. ABIN7869427

The Rabbit Polyclonal anti-APEX2 antibody (ABIN7869427) specifically detects APEX2 in WB, FACS and ELISA. The antibody is reactive with Human samples.

Quick Overview for APEX2 antibody (AA 1-500) (ABIN7869427)

Target: APEX2 (APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APEX2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), ELISA

Product Details anti-APEX2 Antibody

Binding Specificity: AA 1-500

Purpose: APEX2 Antibody

Purification: Affinity purified

Immunogen: Recombinant human protein (amino acids M1-G500) was used as the immunogen for the APEX2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the APEX2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the APEX2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for APEX2

Target: APEX2 (APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2))

Alternative Name: APEX2

Background: APEX2, also called apurinic/apyrimidinic endonuclease like-2, is a member of the apurinic/apyrimidinic (AP) family of endonucleases that initiate the repair of AP sites formed by spontaneous hydrolysis of the N-glycosylic bond, mutagen-induced base release, or damaged-base excision by a DNA repair glycosylase. RT-PCR detected APEX2 expression in HeLa cells, Jurkat cells, and human kidney, brain and fetal brain tissue. The APEX2 gene is mapped to chromosome Xp11.21. APEX2 participates in both nuclear and mitochondrial base excision repair (BER) and it can play a role in processing 3-prime-damaged termini or 3-prime-mismatched nucleotides. Additionally, APEX2 displayed weaker AP site-specific and 3-prime nuclease activities compared to APEX1.

UniProt: Q9UBZ4