SV2C antibody (AA 1-579)

Catalog No. ABIN7869485

This Rabbit Polyclonal antibody specifically detects SV2C in WB, ELISA and FACS. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for SV2C antibody (AA 1-579) (ABIN7869485)

Target: SV2C (Synaptic Vesicle Glycoprotein 2C (SV2C))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SV2C antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-SV2C Antibody

Binding Specificity: AA 1-579

Purpose: SV2C Antibody / Synaptic vesicle glycoprotein 2C

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human SV2C recombinant protein (Position: M1-A579) was used as the immunogen for the SV2C antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SV2C antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SV2C antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SV2C

Target: SV2C (Synaptic Vesicle Glycoprotein 2C (SV2C))

Alternative Name: SV2C

Background: SV2C antibody detects Synaptic vesicle glycoprotein 2C, encoded by the SV2C gene. Synaptic vesicle glycoprotein 2C is a member of the synaptic vesicle protein family that regulates neurotransmitter release and synaptic transmission. SV2C antibody provides researchers with a critical reagent for studying presynaptic mechanisms, vesicle biology, and neurological disease.

Synaptic vesicle glycoprotein 2C belongs to a family that includes SV2A and SV2B, proteins characterized by multiple transmembrane domains and localization to synaptic vesicles. Research using SV2C antibody has shown that it participates in neurotransmitter loading and exocytosis. SV2C regulates vesicular dynamics by influencing calcium sensitivity and fusion efficiency, ensuring precise control of neurotransmitter release at active zones.

Studies with SV2C antibody have demonstrated that it is expressed primarily in subsets of neurons, including dopaminergic and GABAergic populations. This distribution suggests specialized roles in motor control, reward pathways, and inhibitory signaling. Differences in expression between SV2 isoforms highlight unique contributions of SV2C to synaptic diversity.

Synaptic vesicle glycoprotein 2C has been linked to neurological and psychiatric disorders. Research using SV2C antibody has shown that alterations in SV2C expression are associated with Parkinson disease, where it affects dopaminergic transmission. Variations in SV2C have also been implicated in nicotine addiction and response to antiepileptic drugs. These findings emphasize the clinical relevance of SV2C in nervous system disorders.

SV2C antibody is widely used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting quantifies expression levels in brain tissues, immunohistochemistry reveals localization in discrete neuronal populations, and immunofluorescence demonstrates colocalization with other vesicle proteins. These applications make SV2C antibody a valuable reagent for neuroscience research.

By supplying validated SV2C antibody reagents, NSJ Bioreagents supports studies into synaptic vesicle biology, neurotransmitter regulation, and neurological disease. Detection of Synaptic vesicle glycoprotein 2C provides insights into how specialized presynaptic proteins regulate communication within neural circuits.

UniProt: Q496J9