FER antibody (AA 1-804)

Catalog No. ABIN7869568

The Rabbit Polyclonal anti-FER antibody (ABIN7869568) specifically detects FER in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for FER antibody (AA 1-804) (ABIN7869568)

Target: FER (FER Tyrosine Kinase (FER))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FER antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-FER Antibody

Binding Specificity: AA 1-804

Purpose: FER Antibody / FPS/FES-Related tyrosine kinase

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids M1-R804) was used as the immunogen for the FER antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the FER antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the FER antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for FER

Target: FER (FER Tyrosine Kinase (FER))

Alternative Name: FER

Background: FER (FPS/FES-Related tyrosine kinase) also known as TYK3, is an enzyme that in humans is encoded by the FER gene. Fer protein is a member of the FPS/FES family of non-transmembrane receptor tyrosine kinases. By in situ hybridization, Morris et al.(1990) concluded that the FER gene is located at 5q21-q22. Treatment of cells with JMP resulted in the release of FER from the cadherin complex and its accumulation in the integrin complex. The accumulation of FER in the integrin complex and the inhibitory effects of JMP could be reversed with a peptide that mimics the first coiled-coil domain of FER. The results suggested that FER mediates crosstalk between CDH2 and ITGB1. In Fer mutant mice, leukocyte emigration was exaggerated in response to LPS without altering vascular permeability, suggesting that FER has a role in regulating innate immunity.

UniProt: P16591