NKX2-8 antibody (AA 10-123)

Catalog No. ABIN7869678

The Mouse Monoclonal anti-NKX2-8 antibody is suitable to detect NKX2-8 in samples from Human. It has been validated for WB.

Quick Overview for NKX2-8 antibody (AA 10-123) (ABIN7869678)

Target: NKX2-8 (NK2 Homeobox 8 (NKX2-8))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NKX2-8 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: NKX28-2547

Product Details anti-NKX2-8 Antibody

Binding Specificity: AA 10-123

Purpose: NKX2.8 Antibody

Purification: Protein G affinity chromatography

Immunogen: A recombinant human partial protein (amino acids 10-123) was used as the immunogen for the NKX2.8 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the NKX2.8 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the NKX2.8 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for NKX2-8

Target: NKX2-8 (NK2 Homeobox 8 (NKX2-8))

Alternative Name: NKX2.8

Background: The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects.

UniProt: O15522