DDB2 antibody (AA 10-424)

Catalog No. ABIN7869703

The Rabbit Polyclonal anti-DDB2 antibody (ABIN7869703) specifically detects DDB2 in WB, ELISA and FACS. The antibody is reactive with Human samples.

Quick Overview for DDB2 antibody (AA 10-424) (ABIN7869703)

Target: DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DDB2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-DDB2 Antibody

Binding Specificity: AA 10-424

Purpose: DDB2 Antibody

Purification: Affinity purified

Immunogen: Recombinant human protein (amino acids Q10-R424) was used as the immunogen for the DDB2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the DDB2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the DDB2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for DDB2

Target: DDB2 (Damage-Specific DNA Binding Protein 2, 48kDa (DDB2))

Alternative Name: DDB2

Background: DNA damage-binding protein 2 is a protein that in humans is encoded by the DDB2 gene. This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. And this subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene.

UniProt: Q92466

Pathways: DNA Damage Repair