VCP antibody (AA 10-512)

Catalog No. ABIN7869711

The Rabbit Polyclonal anti-VCP antibody is suitable to detect VCP in samples from Human, Mouse, Rat and Monkey. It has been validated for WB, ELISA, FACS and IHC (p).

Quick Overview for VCP antibody (AA 10-512) (ABIN7869711)

Target: VCP (Valosin Containing Protein (VCP))

Reactivity: Human, Mouse, Rat, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VCP antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-VCP Antibody

Binding Specificity: AA 10-512

Purpose: TER ATPase Antibody / VCP / Valosin-containing protein

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids D10-K512) was used as the immunogen for the TER ATPase antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TER ATPase antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the TER ATPase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for VCP

Target: VCP (Valosin Containing Protein (VCP))

Alternative Name: TER ATPase

Background: Valosin-containing protein also called CDC48 is an enzyme that in humans is encoded by the VCP gene. It is a member of the AAA+ (ATPase associated with various activities) protein family. The VCP gene maps to chromosome 9p13.3. It is necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. It is involved in the formation of the transitional endoplasmic reticulum. This gene plays a role in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. It also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites.

UniProt: P55072

Pathways: ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Ubiquitin Proteasome Pathway