BCOR antibody (AA 100-400)

Catalog No. ABIN7869872

This Mouse Monoclonal antibody specifically detects BCOR in IHC (p). It exhibits reactivity toward Human.

Quick Overview for BCOR antibody (AA 100-400) (ABIN7869872)

Target: BCOR (BCL6 Co-Repressor (BCOR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BCOR antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: BCOR-1311

Product Details anti-BCOR Antibody

Binding Specificity: AA 100-400

Purpose: BCOR Antibody / BCL-6 corepressor

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 100-400) from the human protein was used as the immunogen for the BCOR antibody.

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal dilution of the BCOR antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the BCOR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for BCOR

Target: BCOR (BCL6 Co-Repressor (BCOR))

Alternative Name: BCOR

Background: Bcl-6, a transcriptional repressor, can promote or inhibit apoptosis depending on the cell type and also plays an important role in normal immune responses. Bcl-6 negatively regulates NFkB expression, thereby inhibiting NFkB-mediated cellular functions and is frequently found to be deregulated in non-Hodgkin's lymphoma. BCoR (Bcl-6 corepressor) is a 1,755 amino acid protein that associates with histone deacetylases (HDACs) to transcriptionally repress Bcl-6. With ubiquitous expression, BCoR is localized to the nucleus where it interacts with other proteins through its three ANK repeat domains. Mutations in the gene encoding BCoR result in microphthalmia with associated anomalies 2, also known as anophthalmia, which is characterized by variable features, such as renal aplasia, mental retardation, hyospadias, microencephaly and cryptorchidism. There are four isoforms of BCoR which are produced as a result of alternative splicing events.

UniProt: Q6W2J9