MTDH antibody (AA 101-270)

Catalog No. ABIN7869896

This Mouse Monoclonal antibody specifically detects MTDH in WB, FACS and IHC (p). It exhibits reactivity toward Human.

Quick Overview for MTDH antibody (AA 101-270) (ABIN7869896)

Target: MTDH (Metadherin (MTDH))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MTDH antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 2E5G3

Product Details anti-MTDH Antibody

Binding Specificity: AA 101-270

Purpose: AEG-1 Antibody / Astrocyte elevated gene-1 / MTDH / LYRIC

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids D101-Q270) was used as the immunogen for the AEG-1 antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the AEG-1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the AEG-1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for MTDH

Target: MTDH (Metadherin (MTDH))

Alternative Name: AEG-1

Background: MTDH (Metadherin), also known as protein LYRIC or astrocyte elevated gene-1 protein (AEG-1) is a protein that in humans is encoded by the MTDH gene. AEG-1 is involved in HIF-1alpha mediated angiogenesis. AEG-1 also interacts with SND1 and involved in RNA-induced silencing complex (RISC) and plays very important role in RISC and miRNA functions. AEG-1 induces an oncogene called Late SV40 factor (LSF/TFCP2) which is involved in thymidylate synthase (TS) induction and DNA biosynthesis synthesis. Late SV40 factor (LSF/TFCP2) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9). AEG-1 acts as an oncogene in melanoma, malignant glioma, breast cancer and hepatocellular carcinoma. It is highly expressed in these cancers and helps in progression and development of these cancers. It is induced by c-Myc oncogene and plays very important role in anchorage independent growth of cancer cells.

UniProt: Q86UE4

Pathways: Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization