SLIRP antibody (AA 11-109)

Catalog No. ABIN7870062

The Rabbit Polyclonal anti-SLIRP antibody is suitable to detect SLIRP in samples from Human. It has been validated for WB, ELISA, IHC, ICC, IF and FACS.

Quick Overview for SLIRP antibody (AA 11-109) (ABIN7870062)

Target: SLIRP (SRA Stem-Loop Interacting RNA Binding Protein (SLIRP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLIRP antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-SLIRP Antibody

Binding Specificity: AA 11-109

Purpose: SLIRP Antibody / SRA stem-loop interacting RNA-binding protein

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human SLIRP recombinant protein (Position: A11-F109) was used as the immunogen for the SLIRP antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SLIRP antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SLIRP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SLIRP

Target: SLIRP (SRA Stem-Loop Interacting RNA Binding Protein (SLIRP))

Alternative Name: SLIRP

Background: SLIRP antibody detects SRA stem-loop interacting RNA-binding protein, a mitochondrial RNA-binding protein that modulates gene expression, oxidative phosphorylation, and steroid receptor signaling. SLIRP stabilizes mitochondrial mRNAs and participates in post-transcriptional regulation of respiratory chain components. The SLIRP antibody is widely used in mitochondrial biology and molecular endocrinology to study RNA regulation, energy metabolism, and hormone receptor activity.

SLIRP is encoded by the SLIRP gene located on human chromosome 14q13.3. The protein is approximately 111 amino acids long and contains an RNA recognition motif responsible for binding SRA (steroid receptor RNA activator) and mitochondrial transcripts. SLIRP localizes primarily to the mitochondrial matrix but also associates with nuclear hormone receptors, linking energy metabolism with transcriptional regulation.

The SLIRP antibody detects a 12 kilodalton band by western blot and exhibits mitochondrial and nuclear staining under immunofluorescence. SLIRP forms complexes with LRPPRC, ensuring stabilization and translation of mitochondrial mRNAs encoding respiratory complex subunits. Loss of SLIRP leads to reduced mitochondrial translation, impaired oxidative phosphorylation, and decreased ATP production.

Beyond mitochondrial function, SLIRP interacts with steroid receptors such as estrogen receptor alpha and glucocorticoid receptor, modulating their transcriptional activity. By coupling nuclear hormone signaling with mitochondrial bioenergetics, SLIRP coordinates cellular responses to hormonal and metabolic cues. Dysregulation of SLIRP expression contributes to metabolic disorders, neurodegeneration, and certain cancers where mitochondrial dysfunction plays a role.

Because SLIRP integrates transcriptional control and mitochondrial energy metabolism, it represents a valuable target for understanding gene expression coordination and metabolic adaptation. NSJ Bioreagents provides a validated SLIRP antibody optimized for western blot, immunofluorescence, and mitochondrial studies, supporting investigations into RNA processing, hormone receptor function, and oxidative metabolism.

UniProt: Q9GZT3