IL1A antibody (AA 113-271)

Catalog No. ABIN7870149

The Mouse Monoclonal anti-IL1A antibody is suitable to detect IL1A in samples from Human. It has been validated for IHC (p).

Quick Overview for IL1A antibody (AA 113-271) (ABIN7870149)

Target: IL1A (Interleukin 1 alpha (IL1A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL1A antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: IL1A-3981

Product Details anti-IL1A Antibody

Binding Specificity: AA 113-271

Purpose: IL1A Antibody / IL1 alpha (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: A portion of amino acids 113-271 from the human protein was used as the immunogen for the IL1A antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the IL1A antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the IL1A antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for IL1A

Target: IL1A (Interleukin 1 alpha (IL1A))

Alternative Name: IL1A

Background: Two forms of interleukin-1, designated IL-1 alpha and beta, have been described. Although encoded by distinct genes and exhibiting roughly only 25 % sequence identity, IL-1a and IL-1b bind to the same receptor and seem to elicit similar biological responses. IL-1 production is generally thought to be associated with inflammation, but it has also been shown to be expressed during kidney development, thymocyte differentiation and cartilage degradation. IL-1 plays a critical role in the regulation of immune response and inflammation, acting as an activator of T and B lymphocytes and natural killer (NK) cells. In T cells, IL-1 stimulates the production of IL-2 and selectively inhibits IL-4 expression. IL-1 induces B cell proliferation and maturation, and immunoglobulin synthesis. NK cells require IL-1 for production of the anti-pathogen IFN-. IL-1 has also been implicated in several pathological conditions including rheumatoid arthritis, inflammatory bowel disease and atherosclerosis.

UniProt: P01583

Pathways: NF-kappaB Signaling, Autophagy, Cancer Immune Checkpoints