Topoisomerase II alpha antibody (AA 1167-1196)

Catalog No. ABIN7870246

The Rabbit Polyclonal anti-Topoisomerase II alpha antibody (ABIN7870246) specifically detects Topoisomerase II alpha in WB, IF and IHC (p). The antibody is reactive with Human samples.

Quick Overview for Topoisomerase II alpha antibody (AA 1167-1196) (ABIN7870246)

Target: Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Topoisomerase II alpha antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Topoisomerase II alpha Antibody

Binding Specificity: AA 1167-1196

Purpose: Topoisomerase II alpha Antibody / TOP2A

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 1167-1196 from the human protein was used as the immunogen for the Topoisomerase II alpha antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Topoisomerase II alpha antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Topoisomerase II alpha antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Topoisomerase II alpha

Target: Topoisomerase II alpha (TOP2A) (Topoisomerase (DNA) II alpha 170kDa (TOP2A))

Alternative Name: Topoisomerase II alpha

Background: TOP2A encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA.

UniProt: P11388

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases