TRIM21 antibody (AA 12-475)

Catalog No. ABIN7870296

The Rabbit Polyclonal anti-TRIM21 antibody is suitable to detect TRIM21 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA, IF and FACS.

Quick Overview for TRIM21 antibody (AA 12-475) (ABIN7870296)

Target: TRIM21 (Tripartite Motif Containing 21 (TRIM21))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM21 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-TRIM21 Antibody

Binding Specificity: AA 12-475

Purpose: SS-A Antibody / TRIM21

Purification: Affinity purified

Immunogen: Recombinant human protein (amino acids E12-Y475) was used as the immunogen for the SS-A antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SS-A antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SS-A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for TRIM21

Target: TRIM21 (Tripartite Motif Containing 21 (TRIM21))

Alternative Name: SS-A

Background: Tripartite motif-containing protein 21 also known as E3 ubiquitin-protein ligase TRIM21 is a protein that in humans is encoded by the TRIM21 gene. It is mapped to 11p15.4. This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.

UniProt: P19474