LRRC1 antibody (AA 120-497)

Catalog No. ABIN7870313

This Rabbit Polyclonal antibody specifically detects LRRC1 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for LRRC1 antibody (AA 120-497) (ABIN7870313)

Target: LRRC1 (Leucine Rich Repeat Containing 1 (LRRC1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LRRC1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-LRRC1 Antibody

Binding Specificity: AA 120-497

Purpose: LRRC1 Antibody / Leucine-rich repeat-containing protein 1

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human LRRC1 recombinant protein (Position: L120-R497) was used as the immunogen for the LRRC1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the LRRC1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the LRRC1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for LRRC1

Target: LRRC1 (Leucine Rich Repeat Containing 1 (LRRC1))

Alternative Name: LRRC1

Background: LRRC1 antibody detects Leucine-rich repeat-containing protein 1, a scaffolding protein that plays a crucial role in cell polarity, cytoskeletal organization, and signal transduction. LRRC1 is associated with tight junctions and regulates spatial organization of signaling complexes at the plasma membrane. The LRRC1 antibody is used in cell biology and epithelial research to study junctional assembly, polarity establishment, and cell adhesion.

LRRC1 is encoded by the LRRC1 gene located on human chromosome 6p12.2. The protein is approximately 836 amino acids long and contains multiple leucine-rich repeats and coiled-coil regions that facilitate protein-protein interactions. LRRC1 localizes to cell-cell junctions, where it interacts with polarity regulators such as PAR6 and PARD3, forming complexes that define apical and basolateral membrane domains.

The LRRC1 antibody detects a 95 kilodalton band by western blot and reveals junctional and cortical membrane staining under immunofluorescence. Through its interactions, LRRC1 maintains epithelial barrier integrity and contributes to asymmetric signaling required for tissue organization. In neurons, LRRC1 participates in axon guidance and synapse formation by coordinating polarity-related signaling.

Dysregulation of LRRC1 expression has been associated with tumor progression, particularly in epithelial cancers, where loss of polarity contributes to invasiveness and metastasis. LRRC1 also influences cell migration by regulating cytoskeletal rearrangement and adhesion complex turnover. Studies indicate LRRC1 interacts with small GTPases, linking it to actin dynamics and vesicle trafficking.

Because LRRC1 anchors polarity proteins and signaling regulators, it serves as a critical structural determinant of epithelial and neuronal architecture. NSJ Bioreagents provides a validated LRRC1 antibody optimized for its applications, supporting research into cell polarity, adhesion, and cancer biology.

UniProt: Q9BTT6