Recombinant MUC16 antibody (AA 12201-12300)

Catalog No. ABIN7870341

The Rabbit Monoclonal anti-MUC16 antibody is suitable to detect MUC16 in samples from Human. It has been validated for IHC (p).

Quick Overview for Recombinant MUC16 antibody (AA 12201-12300) (ABIN7870341)

Target: MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MUC16 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: OCA125-4505R

Product Details anti-MUC16 Antibody

Binding Specificity: AA 12201-12300

Purpose: Recombinant MUC16 Antibody / CA125 (azide and preservative free)

Purification: Protein A affinity chromatography

Immunogen: A portion of amino acids 12201-12300 from the human protein was used as the immunogen for the recombinant MUC16 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the recombinant MUC16 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the recombinant MUC16 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for MUC16

Target: MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))

Alternative Name: MUC16

Background: CA125 also known as mucin 16, is a member of the mucin family glycoproteins. CA125 is a component of the ocular surface (including the cornea and conjunctiva), the respiratory tract and the female reproductive tract epithelia. Since CA125 is highly glycosylated it creates a hydrophilic environment that acts as a lubricating barrier against foreign particles and infectious agents on the apical membrane of epithelial cells. CA125 reacts with both normal tissues and neoplasms of fallopian tube, endometrium, endocervix and mesothelioma. It does not react with colon cancer. Normal tissues such as breast, liver, skin, kidney and spleen are also negative. Studies have shown that CA125 reacts with approximately 80 % of epithelial ovarian neoplasms of serous, endometrioid, clear cell and undifferentiated types. No reactivity has been shown for mucinous ovarian tumors or in germ cell or hematopoietic tumors. This antibody is a useful aid for classification of a variety of tumors, such as some adenocarcinomas of the colon, breast carcinomas, malignant mesothelioma, uterine adenomatoid tumor, lung bronchoalveolar carcinoma, and ovarian endometrioid and serous carcinomas.

UniProt: Q8WXI7