F2RL3 antibody (AA 13-333)

Catalog No. ABIN7870469

This Rabbit Polyclonal antibody specifically detects F2RL3 in WB, ELISA, IF, IHC (p) and FACS. It exhibits reactivity toward Mouse and Rat.

Quick Overview for F2RL3 antibody (AA 13-333) (ABIN7870469)

Target: F2RL3 (Coagulation Factor II (Thrombin) Receptor-Like 3 (F2RL3))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This F2RL3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-F2RL3 Antibody

Binding Specificity: AA 13-333

Purpose: Par4 Antibody / Pawr / Prostate apoptosis response 4 protein

Purification: Affinity purified

Immunogen: A mouse recombinant partial protein (amino acids T13-R333) was used as the immunogen for the Par4 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Par4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Par4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for F2RL3

Target: F2RL3 (Coagulation Factor II (Thrombin) Receptor-Like 3 (F2RL3))

Alternative Name: Par4

Background: PRKC, apoptosis, WT1, regulator, also known as PAWR or Prostate apoptosis response-4 (Par-4), is a human gene. This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.

UniProt: Q925B0

Pathways: Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process