Claudin 6 antibody (AA 130-159)

Catalog No. ABIN7870491

The Rabbit Polyclonal anti-Claudin 6 antibody is suitable to detect Claudin 6 in samples from Mouse. It has been validated for WB.

Quick Overview for Claudin 6 antibody (AA 130-159) (ABIN7870491)

Target: Claudin 6 (CLDN6)

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Claudin 6 Antibody

Binding Specificity: AA 130-159

Purpose: Claudin 6 Antibody / CLDN6

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 130-159 from the human protein was used as the immunogen for the Claudin 6 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the Claudin 6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Claudin 6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Claudin 6

Target: Claudin 6 (CLDN6)

Alternative Name: Claudin 6

Background: Claudin 6 is a protein that in humans is encoded by the CLDN6 gene. It belongs to the group of claudins. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.

UniProt: Q99808

Pathways: Hepatitis C