PCDHGA2 antibody (AA 132-444)

Catalog No. ABIN7870515

The Rabbit Polyclonal anti-PCDHGA2 antibody is suitable to detect PCDHGA2 in samples from Human and Mouse. It has been validated for WB and ELISA.

Quick Overview for PCDHGA2 antibody (AA 132-444) (ABIN7870515)

Target: PCDHGA2 (Protocadherin gamma Subfamily A, 2 (PCDHGA2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCDHGA2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PCDHGA2 Antibody

Binding Specificity: AA 132-444

Purpose: PCDHGA2 Antibody / Protocadherin gamma A2

Purification: Antigen affinity chromatography

Immunogen: An E.coli-derived human recombinant protein (amino acids R132-D444) was used as the immunogen for the PCDHGA2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PCDHGA2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PCDHGA2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PCDHGA2

Target: PCDHGA2 (Protocadherin gamma Subfamily A, 2 (PCDHGA2))

Alternative Name: PCDHGA2

Background: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

UniProt: Q9Y5H1