RAI1 antibody (AA 14-1906)

Catalog No. ABIN7870617

The Rabbit Polyclonal anti-RAI1 antibody is suitable to detect RAI1 in samples from Human. It has been validated for ELISA, WB, IF, FACS and ICC.

Quick Overview for RAI1 antibody (AA 14-1906) (ABIN7870617)

Target: RAI1 (Retinoic Acid Induced 1 (RAI1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAI1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Product Details anti-RAI1 Antibody

Binding Specificity: AA 14-1906

Purpose: RAI1 Antibody / Retinoic acid-induced protein 1

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human RAI1 recombinant protein (Position: Q14-P1906) was used as the immunogen for the RAI1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the RAI1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the RAI1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for RAI1

Target: RAI1 (Retinoic Acid Induced 1 (RAI1))

Alternative Name: RAI1

Background: RAI1 antibody detects Retinoic acid-induced protein 1, a transcriptional regulator implicated in neurodevelopment, circadian rhythm control, and chromatin remodeling. RAI1 functions as a dosage-sensitive transcription factor that modulates neuronal gene expression and behavior. The RAI1 antibody is widely used in genetics, neurobiology, and developmental studies to explore transcriptional regulation and syndromic neurological disorders.

RAI1 is encoded by the RAI1 gene located on human chromosome 17p11.2. The protein is approximately 1906 amino acids in length and localizes predominantly to the nucleus, where it binds DNA and interacts with chromatin-modifying complexes. RAI1 acts as a transcriptional coactivator that influences gene networks involved in neuronal differentiation, circadian rhythm, and energy balance. Its expression is tightly controlled during embryonic development and in brain regions such as the hypothalamus and cortex.

The RAI1 antibody detects a 220 kilodalton band by western blot and reveals nuclear staining under immunofluorescence microscopy. Haploinsufficiency or deletion of RAI1 causes Smith-Magenis syndrome, characterized by developmental delay, sleep disturbances, and behavioral abnormalities. Conversely, duplication of the RAI1 region is associated with Potocki-Lupski syndrome, illustrating the gene's sensitivity to dosage imbalance.

RAI1 influences circadian rhythm through regulation of CLOCK and BMAL1 targets and modulates neuroplasticity and metabolic pathways. It may also interact with histone-modifying enzymes to alter chromatin accessibility. Dysregulation of RAI1 expression or mutation contributes to neuropsychiatric disorders including autism spectrum disorder, schizophrenia, and intellectual disability.

Because RAI1 governs transcriptional networks essential for neuronal function and rhythmic homeostasis, it serves as a vital link between chromatin dynamics and brain physiology. NSJ Bioreagents provides a validated RAI1 antibody optimized for its applications, supporting research into neurodevelopment, transcriptional control, and genomic disorders.

UniProt: Q7Z5J4