APCS antibody (AA 143-223)

Catalog No. ABIN7870698

The Mouse Monoclonal anti-APCS antibody is suitable to detect APCS in samples from Human. It has been validated for IHC (p).

Quick Overview for APCS antibody (AA 143-223) (ABIN7870698)

Target: APCS (Amyloid P Component, Serum (APCS))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This APCS antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: APCS-3240

Product Details anti-APCS Antibody

Binding Specificity: AA 143-223

Purpose: Serum Amyloid P Antibody

Purification: Protein G affinity chromatography

Immunogen: A recombinant human partial protein (amino acids 143-223) was used as the immunogen for the Serum Amyloid P antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the Serum Amyloid P antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Serum Amyloid P antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for APCS

Target: APCS (Amyloid P Component, Serum (APCS))

Alternative Name: Serum Amyloid P

Background: Serum amyloid P (SAP) is a glycoprotein belonging to the pentraxin family of proteins, which has a characteristic pentameric organization and calciumdependent ligand binding. Secreted by liver epithelial cells, SAP is found in serum and urine. Although the function of SAP has not been clearly established, it has been shown to interact with DNA and histones and is thought to play a role in scavenging nuclear material released from damaged circulating cells. Also designated PTX2, SAP is a precursor of the protein amyloid P component (AP), which is universally associated with the amyloid deposits in all forms of amyloidoses, including Alzheimer s disease. SAP is a decamer of ten identical, noncovalently linked subunits, each of which may be post-translationally modified by glycosylation.

UniProt: P02743