PATZ1 antibody (AA 145-680)

Catalog No. ABIN7870729

The Rabbit Polyclonal anti-PATZ1 antibody (ABIN7870729) specifically detects PATZ1 in WB, ELISA, IF and FACS. The antibody is reactive with Human samples.

Quick Overview for PATZ1 antibody (AA 145-680) (ABIN7870729)

Target: PATZ1 (ZNF278) (Zinc Finger Protein 278 (ZNF278))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PATZ1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-PATZ1 Antibody

Binding Specificity: AA 145-680

Purpose: PATZ1 Antibody / POZ-, AT hook-, and zinc finger-containing protein 1

Purification: Antigen affinity purified

Immunogen: An E.coli-derived human recombinant protein (amino acids M145-Q680) was used as the immunogen for the PATZ1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PATZ1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PATZ1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PATZ1

Target: PATZ1 (ZNF278) (Zinc Finger Protein 278 (ZNF278))

Alternative Name: PATZ1

Background: POZ-, AT hook-, and zinc finger-containing protein 1 is a protein that in humans is encoded by the PATZ1 gene. The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1,22)(p36.1,q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.

UniProt: Q9HBE1