TCF4 antibody (AA 147-176)

Catalog No. ABIN7870740

The Rabbit Polyclonal anti-TCF4 antibody is suitable to detect TCF4 in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for TCF4 antibody (AA 147-176) (ABIN7870740)

Target: TCF4 (Transcription Factor 4 (TCF4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TCF4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TCF4 Antibody

Binding Specificity: AA 147-176

Purpose: TCF4 Antibody / Transcription factor 4

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids Q147-V176) was used as the immunogen for the TCF4 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TCF4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the TCF4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for TCF4

Target: TCF4 (Transcription Factor 4 (TCF4))

Alternative Name: TCF4

Background: Transcription factor 4 (TCF-4) also known as immunoglobulin transcription factor 2 (ITF-2) is a protein that in humans is encoded by the TCF4 gene located on chromosome 18q21.2. This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described.

UniProt: P15884

Pathways: WNT Signaling, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Regulation of Hormone Metabolic Process, Carbohydrate Homeostasis, Stem Cell Maintenance, Protein targeting to Nucleus