TIAM1 antibody (AA 1478-1506)

Catalog No. ABIN7870747

The Rabbit Polyclonal anti-TIAM1 antibody (ABIN7870747) specifically detects TIAM1 in WB. The antibody is reactive with Human samples.

Quick Overview for TIAM1 antibody (AA 1478-1506) (ABIN7870747)

Target: TIAM1 (T-Cell Lymphoma Invasion and Metastasis 1 (TIAM1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIAM1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TIAM1 Antibody

Binding Specificity: AA 1478-1506

Purpose: TIAM1 Antibody / T cell lymphoma invasion and metastasis 1

Purification: Antigen affinity

Immunogen: A portion of amino acids 1478-1506 from the human protein was used as the immunogen for the TIAM1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the TIAM1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the TIAM1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for TIAM1

Target: TIAM1 (T-Cell Lymphoma Invasion and Metastasis 1 (TIAM1))

Alternative Name: TIAM1

Background: TIAM1 is a protein that plays a crucial role in cell migration and invasion. In T cell lymphoma, increased expression of TIAM1 has been associated with enhanced invasive capabilities of cancer cells. TIAM1 promotes the formation of invasive structures called invadopodia, which facilitate cancer cell movement through tissues. Additionally, TIAM1 has been shown to activate signaling pathways that promote metastasis, making it a key player in the spread of T cell lymphoma. Studies have demonstrated that targeting TIAM1 can inhibit T cell lymphoma invasion. By disrupting the activity of TIAM1, researchers have been able to reduce the ability of cancer cells to invade surrounding tissues. This suggests that TIAM1 could be a potential therapeutic target for inhibiting T cell lymphoma invasion and slowing down disease progression. Metastasis is a major concern in T cell lymphoma, as cancer cells can spread to distant organs and tissues, leading to poor prognosis. TIAM1 has been implicated in promoting the metastatic spread of T cell lymphoma cells. By targeting TIAM1, researchers have observed a decrease in the ability of cancer cells to metastasize, highlighting the potential of TIAM1 as a therapeutic target for preventing T cell lymphoma metastasis.

UniProt: Q13009