PPM1F antibody (AA 17-454)

Catalog No. ABIN7871232

The Rabbit Polyclonal anti-PPM1F antibody is suitable to detect PPM1F in samples from Human. It has been validated for WB, ELISA and IF.

Quick Overview for PPM1F antibody (AA 17-454) (ABIN7871232)

Target: PPM1F (Protein Phosphatase 1F (PP2C Domain Containing) (PPM1F))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPM1F antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-PPM1F Antibody

Binding Specificity: AA 17-454

Purpose: PPM1F Antibody / Protein phosphatase 1F / POPX2

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids E17-S454) was used as the immunogen for the PPM1F antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PPM1F antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PPM1F antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for PPM1F

Target: PPM1F (Protein Phosphatase 1F (PP2C Domain Containing) (PPM1F))

Alternative Name: PPM1F

Background: Protein phosphatase 1F is an enzyme that in humans is encoded by the PPM1F gene. The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.

UniProt: P49593

Pathways: Positive Regulation of Endopeptidase Activity