CTLA4 antibody (AA 182-210)

Catalog No. ABIN7871464

The Rabbit Polyclonal anti-CTLA4 antibody (ABIN7871464) specifically detects CTLA4 in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for CTLA4 antibody (AA 182-210) (ABIN7871464)

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTLA4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CTLA4 Antibody

Binding Specificity: AA 182-210

Purpose: CTLA4 Antibody / Cytotoxic T-lymphocyte protein 4 / CD152

Purification: Antigen affinity

Immunogen: A portion of amino acids 182-210 from the human protein was used as the immunogen for this CTLA4 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the CTLA4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Aliquot the CTLA4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CTLA4

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Alternative Name: CTLA4

Background: CTLA4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer.

UniProt: P16410

Pathways: Cancer Immune Checkpoints