OSCAR antibody (AA 19-282)

Catalog No. ABIN7871582

This Rabbit Polyclonal antibody specifically detects OSCAR in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for OSCAR antibody (AA 19-282) (ABIN7871582)

Target: OSCAR (Osteoclast Associated Receptor (OSCAR))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OSCAR antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-OSCAR Antibody

Binding Specificity: AA 19-282

Purpose: OSCAR Antibody / Osteoclast-associated immunoglobulin-like receptor

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human OSCAR recombinant protein (Position: D19-V282) was used as the immunogen for the OSCAR antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the OSCAR antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the OSCAR antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for OSCAR

Target: OSCAR (Osteoclast Associated Receptor (OSCAR))

Alternative Name: OSCAR

Background: OSCAR antibody detects Osteoclast-associated immunoglobulin-like receptor, a transmembrane receptor expressed in osteoclasts and myeloid immune cells. The UniProt recommended name is Osteoclast-associated immunoglobulin-like receptor (OSCAR). This receptor participates in osteoclast differentiation, bone resorption, and immune regulation by transducing activation signals through association with the Fc receptor gamma chain.

Functionally, OSCAR antibody identifies a 287-amino-acid protein containing two extracellular immunoglobulin-like domains and a short cytoplasmic tail. OSCAR acts as a costimulatory receptor on osteoclast precursors, promoting NFATc1 activation and osteoclastogenesis in response to RANKL and ITAM signaling. It also mediates immune cell activation, cytokine secretion, and antigen presentation in monocytes and dendritic cells.

The OSCAR gene is located on chromosome 19q13.4 and is primarily expressed in bone-resorbing osteoclasts, macrophages, and dendritic cells. Its activity links the immune and skeletal systems, contributing to bone remodeling and inflammation-associated bone loss.

Pathologically, elevated OSCAR expression has been observed in rheumatoid arthritis, osteoporosis, and periodontitis, where excessive osteoclast activation leads to bone degradation. Research using OSCAR antibody supports studies in bone metabolism, immune signaling, and inflammatory disease mechanisms.

OSCAR antibody is validated for western blotting, immunohistochemistry, and flow cytometry to detect immunoreceptors involved in osteoclast and immune cell function. NSJ Bioreagents provides OSCAR antibody reagents optimized for studies in bone biology, osteoimmunology, and receptor signaling.

Structurally, Osteoclast-associated immunoglobulin-like receptor contains extracellular Ig-like domains that interact with collagen and intracellular motifs that recruit signaling adapters via Fc receptor gamma chains. This antibody enables examination of OSCAR's role in osteoclast activation and immune crosstalk.

UniProt: Q8IYS5