C5 antibody (AA 19-294)

Catalog No. ABIN7871583

The Rabbit Polyclonal anti-C5 antibody is suitable to detect C5 in samples from Mouse and Rat. It has been validated for WB, ELISA and FACS.

Quick Overview for C5 antibody (AA 19-294) (ABIN7871583)

Target: C5 (Complement Component 5 (C5))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-C5 Antibody

Binding Specificity: AA 19-294

Purpose: C5B Antibody / Complement C5B

Purification: Antigen affinity purified

Immunogen: Recombinant mouse protein (amino acids Q19-D294) was used as the immunogen for the C5B antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the C5B antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the C5B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for C5

Target: C5 (Complement Component 5 (C5))

Alternative Name: C5B

Background: Complement component 5 is a protein that in humans is encoded by the C5 gene. This gene encodes a component of the complement system, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mice with a homozygous mutation in this gene exhibit impaired bone fracture healing and an enhanced inflammatory response in an allergic lung disease model.

UniProt: P06684

Pathways: Complement System, Carbohydrate Homeostasis