Recombinant STING/TMEM173 antibody (AA 190-290)

Catalog No. ABIN7871635

The Rabbit Monoclonal anti-STING/TMEM173 antibody (Clone STING1-8187R) (ABIN7871635) specifically detects STING/TMEM173 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant STING/TMEM173 antibody (AA 190-290) (ABIN7871635)

Target: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This STING/TMEM173 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: STING1-8187R

Product Details anti-STING/TMEM173 Antibody

Binding Specificity: AA 190-290

Purpose: ERIS Antibody / Endoplasmic reticulum interferon stimulator / STING1

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 190-290) from the human protein was used as the immunogen for the ERIS antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the STING1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the STING1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for STING/TMEM173

Target: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Alternative Name: ERIS

Background: TMEM173 (transmembrane protein 173), also called STING1 and ERIS (Endoplasmic reticulum interferon) is a 379 amino acid protein encoded by a gene mapping to human chromosome 5. With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6 % of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.

UniProt: Q86WV6

Pathways: Activation of Innate immune Response