Recombinant STING/TMEM173 antibody (AA 190-290)

Catalog No. ABIN7871637

The Rabbit Monoclonal anti-STING/TMEM173 antibody is suitable to detect STING/TMEM173 in samples from Human. It has been validated for IHC (p).

Quick Overview for Recombinant STING/TMEM173 antibody (AA 190-290) (ABIN7871637)

Target: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This STING/TMEM173 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: STING1-8129R

Product Details anti-STING/TMEM173 Antibody

Binding Specificity: AA 190-290

Purpose: MITA Antibody / Mediator of IRF3 activation / STING1 / ERIS

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 190-290) from the human protein was used as the immunogen for the MITA antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the MITA antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the MITA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for STING/TMEM173

Target: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Alternative Name: MITA

Background: TMEM173 (transmembrane protein 173), also called MITA (Mediator of IRF3 activation), STING1 and ERIS, is a 379 amino acid protein encoded by a gene mapping to human chromosome 5. With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6 % of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.

UniProt: Q86WV6

Pathways: Activation of Innate immune Response