STING/TMEM173 antibody (AA 190-290)

Catalog No. ABIN7871639

This Mouse Monoclonal antibody specifically detects STING/TMEM173 in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for STING/TMEM173 antibody (AA 190-290) (ABIN7871639)

Target: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This STING/TMEM173 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: STING1-7438

Product Details anti-STING/TMEM173 Antibody

Binding Specificity: AA 190-290

Purpose: STING Antibody / MITA / ERIS / TMEM17

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 190-290) from the human protein was used as the immunogen for the STING antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the STING antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the STING antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for STING/TMEM173

Target: STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))

Alternative Name: STING

Background: TMEM173 (transmembrane protein 173), also called MITA, ERIS and STING1, is a 379 amino acid protein encoded by a gene mapping to human chromosome 5. With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6 % of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.

UniProt: Q86WV6

Pathways: Activation of Innate immune Response