NUB1 antibody (AA 190-543)

Catalog No. ABIN7871644

The Rabbit Polyclonal anti-NUB1 antibody (ABIN7871644) specifically detects NUB1 in WB, ELISA, FACS, IHC (p) and IF. The antibody is reactive with Human, Mouse, Monkey and Rat samples.

Quick Overview for NUB1 antibody (AA 190-543) (ABIN7871644)

Target: NUB1 (Negative Regulator of Ubiquitin-Like Proteins 1 (NUB1))

Reactivity: Human, Mouse, Monkey, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUB1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-NUB1 Antibody

Binding Specificity: AA 190-543

Purpose: NUB1 Antibody / NEDD8 ultimate buster 1 / NYREN18

Purification: Antigen affinity purified

Immunogen: An E.coli-derived human recombinant protein (K190-D543) was used as the immunogen for the NUB1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the NUB1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the NUB1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for NUB1

Target: NUB1 (Negative Regulator of Ubiquitin-Like Proteins 1 (NUB1))

Alternative Name: NUB1

Background: NEDD8 µLtimate buster 1 is a protein that in humans is encoded by the NUB1 gene. This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants.

UniProt: Q9Y5A7