Recombinant Filaggrin antibody (AA 198-288)

Catalog No. ABIN7871749

The Rabbit Monoclonal anti-Filaggrin antibody (Clone FLG-3909R) (ABIN7871749) specifically detects Filaggrin in WB. The antibody is reactive with Human samples.

Quick Overview for Recombinant Filaggrin antibody (AA 198-288) (ABIN7871749)

Target: Filaggrin (FLG)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Filaggrin antibody is un-conjugated

Application: Western Blotting (WB)

Clone: FLG-3909R

Product Details anti-Filaggrin Antibody

Binding Specificity: AA 198-288

Purpose: Recombinant Filaggrin Antibody

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 198-288 was used as the immunogen for the recombinant Filaggrin antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the recombinant Filaggrin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the recombinant Filaggrin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Filaggrin

Target: Filaggrin (FLG)

Alternative Name: Filaggrin

Background: Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules.Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.

UniProt: P20930

Pathways: Sensory Perception of Sound, Stem Cell Maintenance