Recombinant Filaggrin antibody (AA 198-288)

Catalog No. ABIN7871751

The Mouse Monoclonal anti-Filaggrin antibody is suitable to detect Filaggrin in samples from Human. It has been validated for IHC (p).

Quick Overview for Recombinant Filaggrin antibody (AA 198-288) (ABIN7871751)

Target: Filaggrin (FLG)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Filaggrin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RFLG-1945

Product Details anti-Filaggrin Antibody

Binding Specificity: AA 198-288

Purpose: Recombinant FLG Antibody / Filaggrin

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 198-288 was used as the immunogen for the recombinant FLG antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the recombinant FLG antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the recombinant FLG antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Filaggrin

Target: Filaggrin (FLG)

Alternative Name: FLG

Background: Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules.Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.

UniProt: P20930

Pathways: Sensory Perception of Sound, Stem Cell Maintenance