Transglutaminase 2 antibody (AA 2-37)

Catalog No. ABIN7871805

The Rabbit Polyclonal anti-Transglutaminase 2 antibody is suitable to detect Transglutaminase 2 in samples from Human. It has been validated for WB and ELISA.

Quick Overview for Transglutaminase 2 antibody (AA 2-37) (ABIN7871805)

Target: Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Transglutaminase 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Transglutaminase 2 Antibody

Binding Specificity: AA 2-37

Purpose: Transglutaminase 2 Antibody / TGM2

Purification: Antigen affinity purified

Immunogen: An E.coli-derived human recombinant protein (A2-Q37) was used as the immunogen for the Transglutaminase 2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Transglutaminase 2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Transglutaminase 2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Transglutaminase 2

Target: Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))

Alternative Name: Transglutaminase 2

Background: Tissue transglutaminase, also called TGC, is a 78- kDa, calcium dependent enzyme of the protein-glutamine gamma-glutamyltransferases family. By fluorescence in situ hybridization (FISH), this gene is mapped in 20q11.23. Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease.

UniProt: P21980

Pathways: Tube Formation, Thromboxane A2 Receptor Signaling