KISS1 antibody (AA 20-52)

Catalog No. ABIN7871877

The Rabbit Polyclonal anti-KISS1 antibody is suitable to detect KISS1 in samples from Human. It has been validated for WB and IHC (p).

Quick Overview for KISS1 antibody (AA 20-52) (ABIN7871877)

Target: KISS1 (KiSS-1 Metastasis-Suppressor (KISS1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KISS1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-KISS1 Antibody

Binding Specificity: AA 20-52

Purpose: KiSS-1 Antibody / KISS1

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 20-52 from the human protein was used as the immunogen for the KiSS-1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the KiSS-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the KiSS-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for KISS1

Target: KISS1 (KiSS-1 Metastasis-Suppressor (KISS1))

Alternative Name: KiSS-1

Background: Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell- matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine- tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.

UniProt: Q15726

Pathways: Positive Regulation of Peptide Hormone Secretion