Recombinant Syndecan 1 antibody (AA 200-300)

Catalog No. ABIN7871952

The Rabbit Monoclonal anti-Syndecan 1 antibody is suitable to detect Syndecan 1 in samples from Human. It has been validated for IHC (p).

Quick Overview for Recombinant Syndecan 1 antibody (AA 200-300) (ABIN7871952)

Target: Syndecan 1 (SDC1)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Syndecan 1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: SDC1-4378R

Product Details anti-Syndecan 1 Antibody

Binding Specificity: AA 200-300

Purpose: Recombinant Syndecan-1 Antibody / CD138 (azide and preservative free)

Purification: Protein A affinity chromatography

Immunogen: A portion of amino acids 200-300 from the human protein was used as the immunogen for the recombinant Syndecan-1 antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the recombinant Syndecan-1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the recombinant Syndecan-1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Syndecan 1

Target: Syndecan 1 (SDC1)

Alternative Name: Syndecan-1

Background: CD138, also designated syndecan-1, is a member of the syndecan family of four transmembrane spanning proteins capable of binding to heparan sulfate and chondroitin sulfate molecules. The syndecans main functions are to control cell growth and differentiation as well as to maintain cell adhesion and cell migration. Under normal conditions CD138/Syndecan-1 is predominantly expressed on mature plasma cells and early preB-cells, while other haematolymphoid cells are negative. Various types of epithelial cells are also CD138/Syndecan-1 positive. Squamous epithelial cells show strong membranous and some cytoplasmic staining, except for the mature superficial squamous epithelial cells which are unstained. Mature mesenchymal and neural tissues are not stained. Among haematolymphoid neoplasms, it is expressed in practically all cases of plasma cell malignancies. Among non-haematolymphoid neoplasms the expression of CD138 is found in various types of carcinoma. In the following, the large majority of cases is CD138 positive: skin squamous cell carcinoma and basal cell carcinoma, colorectal adenocarcinoma, cholangiocarcinoma, transitional cell carcinoma, endometrial adenocarcinoma, ductal and lobular breast carcinoma, hepatocellular carcinoma, renal cell carcinoma, and lung adenocarcinoma. CD138/Syndecan-1 is a very sensitive and specific marker for identification of plasma cells and plasma cell differentiation within haematolymphoid tissues in benign and neoplastic conditions.

UniProt: P18827

Pathways: Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Lipid Metabolism