IDO2 antibody (AA 200-350)

Catalog No. ABIN7871972

This Mouse Monoclonal antibody specifically detects IDO2 in WB, ELISA and IHC (p). It exhibits reactivity toward Human.

Quick Overview for IDO2 antibody (AA 200-350) (ABIN7871972)

Target: IDO2 (Indoleamine 2,3-Dioxygenase 2 (IDO2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IDO2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: IDO2-2638

Product Details anti-IDO2 Antibody

Binding Specificity: AA 200-350

Purpose: INDOL1 Antibody / IDO2 (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 200-350 was used as the immunogen for the INDOL1 antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the INDOL1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the INDOL1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for IDO2

Target: IDO2 (Indoleamine 2,3-Dioxygenase 2 (IDO2))

Alternative Name: INDOL1

Background: IDO2 is a presumptive immunomodulatory gene based on its close structural relationship to IDO1 and its expression in a variety of antigen-presenting cell types. Both IDO1 and IDO2 will catabolize tryptophan to kynurenine. Biochemical studies indicate that both enzymes are similarly robust in catabolic activity, although the in vitro conditions required for IDO2 to manifest the same level of activity differ somewhat from IDO1. However, whether IDO2 is active as a tryptophan catabolizing enzyme in human dendritic cells has been disputed. Further work is needed to conclusively determine that IDO1 and IDO2 are similar in their preference for substrates and reaction pathways to generate product. A non-redundant function for IDO2 relative to IDO1 is suggested by their rather distinct expression patterns and response to extracellular stimuli.

UniProt: Q6ZQW0