PAX2A antibody (AA 200-400)

Catalog No. ABIN7872035

This Mouse Monoclonal antibody specifically detects PAX2A in IHC (p). It exhibits reactivity toward Human.

Quick Overview for PAX2A antibody (AA 200-400) (ABIN7872035)

Target: PAX2A (Paired Box Gene 2a (PAX2A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PAX2A antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: PAX2-2994

Product Details anti-PAX2A Antibody

Binding Specificity: AA 200-400

Purpose: PAX2 Antibody

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein (within amino acids 200-400) from the human protein was used as the immunogen for the PAX2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PAX2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the PAX2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for PAX2A

Target: PAX2A (Paired Box Gene 2a (PAX2A))

Alternative Name: PAX2

Background: Recognizes a protein of 42 kDa, which is identified as PAX2. It is a member of the paired box family of transcription factors, which is required for development and proliferation of the kidney, brain, and mullerian organs. PAX2 genes contain a highly conserved DNA sequence within the paired box region, which encodes a DNA-binding domain, enabling PAX proteins to bind the promoters of specific genes to transcriptionally regulate their expression. PAX2 is specifically expressed in the developing central nervous system, eye, ear, and urogenital tract, and is essential for the development of these organs. In normal adult tissues PAX2 was mainly detected in the urogenital system, including kidney, ureteric epithelium, fallopian tube epithelium, ovary and uterus. In tumors, PAX2 has been detected in renal cell carcinomas, Wilms' tumors, nephrogenic adenomas and papillary serous carcinoma of the ovary. PAX2 has been used as a marker for the identification of renal cell carcinoma and ovarian carcinoma by immunohistochemistry.

UniProt: Q02962

Pathways: Carbohydrate Homeostasis, Stem Cell Maintenance, Tube Formation