CFHR5 antibody (AA 203-231)

Catalog No. ABIN7872079

The Rabbit Polyclonal anti-CFHR5 antibody (ABIN7872079) specifically detects CFHR5 in WB, FACS and IHC (p). The antibody is reactive with Human samples.

Quick Overview for CFHR5 antibody (AA 203-231) (ABIN7872079)

Target: CFHR5 (Complement Factor H-Related 5 (CFHR5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CFHR5 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CFHR5 Antibody

Binding Specificity: AA 203-231

Purpose: FHR-5 Antibody / Complement factor H-related protein 5 / CFHR5

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 203-231 from the human protein was used as the immunogen for the FHR-5 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the FHR-5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the FHR-5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CFHR5

Target: CFHR5 (Complement Factor H-Related 5 (CFHR5))

Alternative Name: FHR-5

Background: CFHR5 / FHR-5 is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS). [provided by RefSeq].

UniProt: Q9BXR6