SPG20 antibody (AA 205-631)

Catalog No. ABIN7872097

The Rabbit Polyclonal anti-SPG20 antibody (ABIN7872097) specifically detects SPG20 in WB, ELISA and FACS. The antibody is reactive with Human and Rat samples.

Quick Overview for SPG20 antibody (AA 205-631) (ABIN7872097)

Target: SPG20 (Spastic Paraplegia 20 (Troyer Syndrome) (SPG20))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPG20 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-SPG20 Antibody

Binding Specificity: AA 205-631

Purpose: Spartin Antibody / SPART

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids H205-V631) was used as the immunogen for the Spartin antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Spartin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Spartin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SPG20

Target: SPG20 (Spastic Paraplegia 20 (Troyer Syndrome) (SPG20))

Alternative Name: Spartin

Background: Spartin is a protein that in humans is encoded by the SPART gene. This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome).

UniProt: Q8N0X7

Pathways: Regulation of Cell Size, SARS-CoV-2 Protein Interactome