Geminin antibody (AA 21-196)

Catalog No. ABIN7872144

The Rabbit Polyclonal anti-Geminin antibody is suitable to detect Geminin in samples from Human and Mouse. It has been validated for WB, IF, ELISA, IHC (p) and FACS.

Quick Overview for Geminin antibody (AA 21-196) (ABIN7872144)

Target: Geminin (GMNN) (Geminin, DNA Replication Inhibitor (GMNN))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Geminin antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-Geminin Antibody

Binding Specificity: AA 21-196

Purpose: Geminin Antibody / GMNN

Purification: Affinity purified

Immunogen: An E. coli-derived human protein (amino acids V21-E196) was used as the immunogen for the Geminin antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Geminin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Geminin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Geminin

Target: Geminin (GMNN) (Geminin, DNA Replication Inhibitor (GMNN))

Alternative Name: Geminin

Background: Geminin, DNA replication inhibitor, also known as GMNN, is a protein in humans encoded by the GMNN gene. This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16.

UniProt: O75496

Pathways: EGFR Signaling Pathway, DNA Replication