FERMT1 antibody (AA 216-677)

Catalog No. ABIN7872244

The Mouse Monoclonal anti-FERMT1 antibody (Clone 4A5-14) (ABIN7872244) specifically detects FERMT1 in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for FERMT1 antibody (AA 216-677) (ABIN7872244)

Target: FERMT1 (Fermitin Family Member 1 (FERMT1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FERMT1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 4A5-14

Product Details anti-FERMT1 Antibody

Binding Specificity: AA 216-677

Purpose: Kindlin-1 Antibody / KIND1

Purification: Protein G affinity chromatography

Immunogen: Amino acids 216-677 from the human protein were used as the immunogen for the Kindlin-1 antibody.

Isotype: IgG2a

Application Details

Application Notes: Optimal dilution of the Kindlin-1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Kindlin-1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for FERMT1

Target: FERMT1 (Fermitin Family Member 1 (FERMT1))

Alternative Name: Kindlin-1

Background: Kindlin-1 (also known as KIND1, KINDLERIN, UNC112-RELATED PROTEIN 1 (URP1) is an important component of cell-extracellular matrix adhesion. Kindlin-1 is involved in cell adhesion, possibly via its interaction with integrins and may mediate TGF-beta 1 signaling during tumor progression. Kindlin-1 has been shown to be significantly upregulated in lung and colon carcinomas. Mutations in the kindlin-1 gene, FERMT1, causes Kindler syndrome. Kindler syndrome is an autosomal recessive disorder characterized by neonatal blistering, sun sensitivity, atrophy, abnormal pigmentation and fragility of the skin. We have developed monoclonal anti-kidlin-1 antibodies. This monoclonal antibody recognizes kindlin-1 in multiple assays including Western blotting, immunoprecipitation, immunohistochemical and immunofluorescent staining.

UniProt: Q9BQL6