Growth Hormone 1 antibody (AA 22-217)

Catalog No. ABIN7872313

The Rabbit Polyclonal anti-Growth Hormone 1 antibody (ABIN7872313) specifically detects Growth Hormone 1 in WB, ELISA and FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Growth Hormone 1 antibody (AA 22-217) (ABIN7872313)

Target: Growth Hormone 1 (GH1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Growth Hormone 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-Growth Hormone 1 Antibody

Binding Specificity: AA 22-217

Purpose: GH1 Antibody / Growth Hormone

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human GH1 recombinant protein (Position: Q22-F217) was used as the immunogen for the GH1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the GH1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the GH1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Growth Hormone 1

Target: Growth Hormone 1 (GH1)

Alternative Name: GH1

Background: GH1 antibody detects Growth hormone 1, a peptide hormone secreted by the anterior pituitary gland that stimulates growth, metabolism, and cellular regeneration. GH1 belongs to the somatotropin/prolactin family of hormones and exerts its effects through activation of the growth hormone receptor (GHR) and downstream JAK-STAT signaling pathways. The GH1 antibody is used in endocrinology and metabolic research to study growth regulation, pituitary physiology, and hormone secretion mechanisms.

GH1 is encoded by the GH1 gene located on human chromosome 17q24.2. The mature protein is approximately 22 kilodaltons and derived from a larger precursor that undergoes signal peptide removal and disulfide bond formation in the endoplasmic reticulum. GH1 is stored in secretory granules and released into circulation in response to hypothalamic growth hormone-releasing hormone (GHRH) and inhibited by somatostatin. It plays major roles in postnatal growth, bone development, and metabolic homeostasis.

The GH1 antibody detects the 22 kilodalton hormone by western blot and shows strong cytoplasmic granule staining in pituitary somatotrophs by immunofluorescence. GH1 binds to its receptor on target tissues, activating JAK2 and STAT5 pathways that induce insulin-like growth factor 1 (IGF1) production in the liver and peripheral tissues. Through IGF1 and direct signaling, GH1 stimulates protein synthesis, lipolysis, and glucose utilization.

Aberrations in GH1 production cause growth disorders, including gigantism and acromegaly from overproduction, or growth hormone deficiency due to pituitary malfunction or genetic mutation. Outside growth regulation, GH1 contributes to immune function, cardiac performance, and metabolic adaptation under stress conditions. Elevated GH1 and IGF1 signaling are also linked to cancer cell proliferation and survival.

Because of its central endocrine function, GH1 serves as a key biomarker in clinical diagnostics and metabolic studies. NSJ Bioreagents provides a validated GH1 antibody optimized for western blot, flow cytometry, and hormone localization assays, supporting detailed investigation of pituitary function, growth signaling, and endocrine regulation.

UniProt: P01241

Pathways: NF-kappaB Signaling, JAK-STAT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Response to Growth Hormone Stimulus, Regulation of Hormone Biosynthetic Process