Recombinant Synaptophysin antibody (AA 224-313)

Catalog No. ABIN7872392

This Mouse Monoclonal antibody specifically detects Synaptophysin in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant Synaptophysin antibody (AA 224-313) (ABIN7872392)

Target: Synaptophysin (SYP)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Synaptophysin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RSYP-8807

Product Details anti-Synaptophysin Antibody

Binding Specificity: AA 224-313

Purpose: SYP Antibody / Synaptophysin

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 224-313) from the human protein was used as the immunogen for the SYP antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the SYP antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the SYP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Synaptophysin

Target: Synaptophysin (SYP)

Alternative Name: SYP

Background: This recombinant mouse monoclonal antibody recognizes a protein of 38 kDa that is identified as synaptophysin. It is an N-glycosylated integral membrane protein found in neurons and endocrine cells. Synaptophysin contains four transmembrane domains and may function as a gap junction-like channel.This antibody identifies normal neuroendocrine cells and neuroendocrine neoplasms. Diffuse, finely granular, cytoplasmic staining is observed, which probably correlates with the distribution of the antigen within neurosecretory vesicles. Synaptophysin is an independent, broad-range marker of neural and neuroendocrine differentiation.

UniProt: P08247

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity