Prohibitin 2 antibody (AA 225-255)

Catalog No. ABIN7872401

This Rabbit Polyclonal antibody specifically detects Prohibitin 2 in WB and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Prohibitin 2 antibody (AA 225-255) (ABIN7872401)

Target: Prohibitin 2 (PHB2)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Prohibitin 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Prohibitin 2 Antibody

Binding Specificity: AA 225-255

Purpose: Prohibitin 2 Antibody / PHB2

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 225-255 from the human protein was used as the immunogen for the Prohibitin 2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Prohibitin 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Prohibitin 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Prohibitin 2

Target: Prohibitin 2 (PHB2)

Alternative Name: Prohibitin 2

Background: PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. It functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. It competes with NCOA1 for modulation of ER transcriptional activity and is probably involved in regulating mitochondrial respiration activity and in aging.

UniProt: Q99623

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling