RSRC2 antibody (AA 226-434)

Catalog No. ABIN7872410

This Rabbit Polyclonal antibody specifically detects RSRC2 in WB, ELISA, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for RSRC2 antibody (AA 226-434) (ABIN7872410)

Target: RSRC2 (arginine/serine-Rich Coiled-Coil 2 (RSRC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RSRC2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-RSRC2 Antibody

Binding Specificity: AA 226-434

Purpose: RSRC2 Antibody / Arginine/serine-rich coiled-coil protein 2

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human RSRC2 recombinant protein (Position: F226-V434) was used as the immunogen for the RSRC2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the RSRC2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the RSRC2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for RSRC2

Target: RSRC2 (arginine/serine-Rich Coiled-Coil 2 (RSRC2))

Alternative Name: RSRC2

Background: RSRC2 antibody detects Arginine/serine-rich coiled-coil protein 2, a nuclear splicing factor that regulates pre-mRNA processing and alternative splicing. The UniProt recommended name is Arginine/serine-rich coiled-coil protein 2 (RSRC2). This serine/arginine-rich (SR) protein family member modulates spliceosome assembly and mRNA maturation, influencing gene expression across multiple tissues.

Functionally, RSRC2 antibody identifies a 477-amino-acid protein localized to nuclear speckles where it associates with splicing machinery components. RSRC2 facilitates exon recognition and splice site selection through interactions with U2AF and SR proteins, ensuring accurate pre-mRNA splicing. It also acts as a transcriptional co-regulator linking splicing to gene expression control.

The RSRC2 gene is located on chromosome 12q24.31 and is widely expressed, with enrichment in brain, heart, and testis. RSRC2 activity supports tissue-specific splicing patterns essential for cellular differentiation and development. It dynamically redistributes within the nucleus in response to transcriptional and stress signals, reflecting its role in gene expression regulation.

Pathologically, RSRC2 dysregulation has been implicated in neurodegenerative disease, cancer, and cardiovascular disorders. Altered RSRC2 expression disrupts mRNA splicing fidelity and may affect tumor suppressor or oncogene expression. Research using RSRC2 antibody aids in studies of RNA processing, splicing regulation, and gene expression control.

RSRC2 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect splicing regulators and nuclear speckle proteins. NSJ Bioreagents offers RSRC2 antibody reagents optimized for RNA biology, molecular genetics, and transcriptional regulation research.

Structurally, Arginine/serine-rich coiled-coil protein 2 contains SR repeats mediating protein interactions and a coiled-coil region that promotes nuclear localization and complex formation. This antibody enables detailed analysis of RSRC2's role in co-transcriptional mRNA processing and cellular homeostasis.

UniProt: Q7L4I2