Recombinant T-Box 1 antibody (AA 235-435)

Catalog No. ABIN7872615

The Rabbit Monoclonal anti-T-Box 1 antibody is suitable to detect T-Box 1 in samples from Human. It has been validated for IHC (p).

Quick Overview for Recombinant T-Box 1 antibody (AA 235-435) (ABIN7872615)

Target: T-Box 1 (TBX1)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This T-Box 1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: TBXT-7711R

Product Details anti-T-Box 1 Antibody

Binding Specificity: AA 235-435

Purpose: Brachyury Antibody / TBXT / Protein T (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 235-435) from the human protein was used as the immunogen for the Brachyury antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the Brachyury antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the Brachyury antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for T-Box 1

Target: T-Box 1 (TBX1)

Alternative Name: Brachyury

Background: The T-box gene family consists of members that share a unique DNA binding domain. The best characterized T-box (Tbx) gene, brachyury or T, encodes a transcription factor that plays an important role in early vertebrate development. Tbx genes are a family of developmental regulators with more than 20 members recently identified among invertebrates and vertebrates. Mutations in Tbx genes have been found to cause several human diseases. The understanding of functional mechanisms of Tbx products has come mainly from the prototypical T/brachyury protein, which is a transcription activator. The T-domain is a highly conserved DNA-binding motif originally defined in brachyury and characteristic of the Tbx family of transcription factors. The murine brachyury (T) gene is required in posterior mesoderm formation and axial development. Mutant embryos lacking T gene function are deficient in notochord differentiation and posterior mesoderm formation, but develop anterior mesoderm.

UniProt: O15178

Pathways: Retinoic Acid Receptor Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Regulation of Muscle Cell Differentiation