SPTAN1 antibody (AA 2351-2475)

Catalog No. ABIN7872625

The Mouse Monoclonal anti-SPTAN1 antibody (Clone SPTAN1-3351) (ABIN7872625) specifically detects SPTAN1 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for SPTAN1 antibody (AA 2351-2475) (ABIN7872625)

Target: SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SPTAN1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: SPTAN1-3351

Product Details anti-SPTAN1 Antibody

Binding Specificity: AA 2351-2475

Purpose: SPTAN1 Antibody / Alpha II Spectrin / Alpha Fodrin / NEAS (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: A recombinant human partial protein (amino acids 2351-2475) was used as the immunogen for this SPTAN1 antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the SPTAN1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the SPTAN1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for SPTAN1

Target: SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

Alternative Name: SPTAN1

Background: Spectrin, an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane, is essential in determining the properties of the membrane including its shape and deformability. Spectrins function as membrane organizers and stabilizers, composed of nonhomologous and chains, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. Spectrin I and spectrin I are present in erythrocytes, whereas spectrin II (also designated fodrin ) and spectrin II (also designated fodrin ) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Activation of calpain results in the breakdown of spectrin II, a neuronal cytoskeleton protein.

UniProt: Q13813

Pathways: Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization