FcRn antibody (AA 24-215)

Catalog No. ABIN7872674

This Mouse Monoclonal antibody specifically detects FcRn in IHC (p). It exhibits reactivity toward Human.

Quick Overview for FcRn antibody (AA 24-215) (ABIN7872674)

Target: FcRn (neonatal Fc Receptor (FcRn))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FcRn antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: FCGRT-2932

Product Details anti-FcRn Antibody

Binding Specificity: AA 24-215

Purpose: FCGRT Antibody / FcRn (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: A recombinant human partial protein (amino acids 24-215) was used as the immunogen for the FCGRT antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the FCGRT antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the FCGRT antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for FcRn

Target: FcRn (neonatal Fc Receptor (FcRn))

Alternative Name: FCGRT

Background: This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. FCGRT is present in the intestinal epithelium of neonates and mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn to acquire passive immunity. FCGRT is comprised of a heavy chain and -2-Microglobulin. FCGRT localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal degradation.

UniProt: P55899

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process