FcRn antibody (AA 24-215)

Catalog No. ABIN7872675

The Mouse Monoclonal anti-FcRn antibody is suitable to detect FcRn in samples from Human. It has been validated for IHC (p).

Quick Overview for FcRn antibody (AA 24-215) (ABIN7872675)

Target: FcRn (neonatal Fc Receptor (FcRn))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FcRn antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: FCGRT-2932

Product Details anti-FcRn Antibody

Binding Specificity: AA 24-215

Purpose: FCGRT Antibody / FcRn

Purification: Protein G affinity chromatography

Immunogen: A recombinant human partial protein (amino acids 24-215) was used as the immunogen for the FCGRT antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the FCGRT antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the FCGRT antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for FcRn

Target: FcRn (neonatal Fc Receptor (FcRn))

Alternative Name: FCGRT

Background: This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. FCGRT is present in the intestinal epithelium of neonates and mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn to acquire passive immunity. FCGRT is comprised of a heavy chain and -2-Microglobulin. FCGRT localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal degradation.

UniProt: P55899

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process